Special Issues

Special Issue Title: Stroke neurology (Ischemic stroke; care, treatment and neuroprotection)

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· Deadline for manuscript submissions:  1 October 2020

Special Issue Editor

Guest Editor

Associate Prof. Dr. Thomas I. Nathaniel

Department of Biomedical Sciences, School of Medicine Greenville, University of South Carolina, USA

Website | E-Mail

Interests: Molecular neuroscience, cellular neuroscience, system neuroscience

Special Issue Information

Dear Colleagues,

Ischemic stroke contributes to more 6 million deaths every year, and an estimated 250 million people with stroke related disability has been proposed for year 2035. Advances in the care of ischemic stroke include the use of reperfusion therapy to re-establish blood flow to the areas of brain that are ischemic in acute ischemic stroke patients. Such options include the use of mechanical thrombectomy and recombinant tissue plasminogen activator (or IV rtPA). Telestroke networks have also been established to allow stroke care to be accessible to all geographical locations. While the use of several neuroprotective agents are yet to translate to clinical care, several innovative efforts have been proposed to improve basic and clinical research. This includes robust and collaborative efforts between the preclinical and clinical stroke research community. Such efforts may result in reproducibility of results for improved data that can lead to target validation that may carefully mimics clinical trials. With improvements in stroke care and neuroprotective research, challenges faced by pre-and clinical stroke research may lead to improved translational success. We welcome original submissions from a wide variety of disciplines. Submissions from basic and clinical cases and review articles integrating the following subtopics; markers, genetics, physiology, epidemiology, risk factors, care, treatment, and under-served populations will be considered. While we welcome submissions from a broad range of manuscripts, we are mainly interested in studies that address issues relating to;

● Different research outputs and methods in ischemic stroke

● Stroke care, treatment and clinical outcomes

● Different models of ischemic stroke

● Neuroprotection and treatment of ischemic stroke

● Pathogenesis and pathology of ischemic stroke

● Therapeutic neuroprotection

Associate Prof. Dr. Thomas I. Nathaniel 

Guest Editor


Manuscript Submission Information

Manuscripts should be submitted online at https://jour.ipublishment.com/imr/access/login by registering and logging into this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Integrative Neuroscience is an international peer-reviewed open access quarterly journal published by IMR Press.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is $1500. We normally offer a discount greater than 30% (APC: $1050) to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.


Neuroprotection, Ischemic stroke, care, treatment, telestroke


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Published Papers (2 papers)
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Relationship between recovery of motor function and neuropsychological functioning in cerebral infarction patients: the importance of social functioning in motor recovery
Min Cheol Chang, Sung-Won Park, Byung-Joo Lee, Donghwi Park
Journal of Integrative Neuroscience    2020, 19 (3): 405-411.   DOI: 10.31083/j.jin.2020.03.175
Abstract352)   HTML41)    PDF(pc) (235KB)(662)       Save

Impaired motor function is a common disabling sequela after stroke. It is closely associated with the patient’s quality of life and independence. Neuropsychological dysfunctions also frequently occur in stroke patients. In this paper, we evaluate the relationship between the recovery of motor function and neuropsychological functions, including cognition, language, emotion, behavior, personality, and social interaction, to provide appropriate and effective therapy for stroke patients. Motor function, neuropsychological status, social functioning, as well as emotional aspects such as depression and anxiety symptoms, were initially evaluated one month after cerebral infarction onset. The evaluations were repeated three months after the onset. Motor function was assessed with the Modified Barthel Index. The neuropsychological status was evaluated using the Mini-Mental State Examination, Global Deterioration Scale, digit span test, Korean-Boston Naming Test, Vineland Social Maturity Scale, Neuropsychiatric Inventory, Beck’s Depression Inventory, and Beck Anxiety Inventory. In the results, the Modified Barthel Index, Mini-Mental State Examination, Global Deterioration Scale, digit span test, and Vineland Social Maturity Scale were significantly different between the two-time points (P < 0.05). Initial Social Maturity Scale Social Age and Social Maturity Scale Social Quotient categories of the Vineland Social Maturity Scale and Mini-Mental State Examination scores were significantly correlated with Modified Barthel Index improvement (P < 0.05). The amount of change in the Social Maturity Scale Social Age and Social Maturity Scale Social Quotient scores was significantly correlated with Modified Barthel Index improvement (P < 0.05). In multiple linear regression analysis, only the initial Social Maturity Scale Social Quotient score and the amount of score change in Social Maturity Scale Social Quotient showed a significant correlation with Modified Barthel Index improvement (P < 0.05).Social function and interaction are important in motor recovery of ischemic stroke patients.

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Mortality prediction of ischemic stroke patients without thrombectomy by blood total antioxidant capacity
Leonardo Lorente, María M. Martín, Agustín F. González-Rivero, Antonia Pérez-Cejas, Pedro Abreu-González, Rafael Sabatel, Luis Ramos-Gómez, Mónica Argueso, Jordi Solé-Violán, Juan J. Cáceres, Alejandro Jiménez, Victor García-Marín
Journal of Integrative Neuroscience    2020, 19 (3): 501-506.   DOI: 10.31083/j.jin.2020.03.101
Abstract189)   HTML10)    PDF(pc) (1644KB)(263)       Save

It has been previously established that total antioxidant capacity concentrations of blood on the first day of ischemic stroke could predict mortality. Therefore, our study objective was to determine whether total antioxidant capacity concentrations in the blood during the first week of a cerebral infarction could help predict mortality. We included severe and malignant middle cerebral artery infarction patients (affecting 50% or more of the territory in computed tomography and a score of nine or fewer points in the Glasgow Coma Scale). Serum total antioxidant capacity concentrations were determined on days first, fourth, and eighth of the diagnosis of a malignant middle cerebral artery infarction. Higher serum total antioxidant capacity concentrations at first (P< 0.001), fourth (P< 0.001), and eighth (P = 0.003) day were found in non-surviving patients than in surviving ones. Serum total antioxidant capacity concentrations on first, fourth and eighth day of malignant middle cerebral artery infarction had an area under curve (95% Confidence Intervals) for 30-day mortality prediction of 0.86 (0.75-0.93; P<0.001), 0.87 (0.74-0.95; P< 0.001) and 0.79 (0.64-0.90; P = 0.004)), respectively. Thus, the potential use of serum total antioxidant capacity concentrations at any time during the first 7 days of a severe malignant middle cerebral artery infarction without thrombectomy to predict mortality was the main novel finding of our study.

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