Special Issues

Special Issue Title: Neuropeptides in the central nervous system that impact the affective spectrum

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·  Deadline for manuscript submissions: 30 April 2021



Special Issue Editor

Guest Editor

Dr. Alessandro Castorina

Laboratory of Cellular and Molecular Neuroscience, School of Life Sciences, Faculty of Science, University of Technology Sydney, Australia

Website | E-Mail

Interests: Neuroscience, neurobiology of neuropeptides, Multiple Sclerosis, neuroinflammation, Parkinson's disease, affective spectrum disorders



Special Issue Information

Dear Colleagues,


Since the discovery of neuropeptides about sixty years ago, a progressively increasing number of investigations have arisen, indicating the emerging interest in understanding the role elicited by these ‘neuromodulators’ in the central nervous system. Whilst initially considered as mere hypothalamic secretions involved in the control of general homeostatic functions, neuropeptides have been found to act as pleiotropic agents that elicit neuroprotective, neuroendocrine and neuroimmune functions.

Recent knowledge suggests that several classes of neuropeptides are produced and secreted by discreet brain regions to control a number of motivated behaviours.

In health conditions, motivated behaviours are essential for individuals to survive and adapt to the changing environment. However, exposure to acute or chronic stressors such as physical traumas and chronic pain states, dysfunctional life styles, wrong dietary habits or pre-existing neurodegenerative conditions can lead to the development of a broad spectrum of maladaptive behaviours of the affective spectrum that culminate in psychiatric conditions. Therefore, in view of the major role elicited by neuropeptides in the control of motivated behaviours, understanding their neurobiology, the underlying molecular mechanisms and interactions in response to these triggers becomes necessary to define viable solutions to mitigate the maladaptive behaviour and provide the basis for an effective diagnosis, prevention and treatment.

The goal of this Special Issue is to highlight recent advances on the regulatory role of neuropeptides in the context of feeding, sexual, sleeping, maternal and social behaviours, among others. Original contributions addressing the involvement of neuropeptides in the development of mental illnesses characterised by reduced or excessive motivational responses such as attention deficit hyperactivity disorder, autism spectrum disorders, bipolar disorder, borderline personality disorder, post-traumatic stress disorder and foetal alcohol spectrum disorders will also be considered.


Dr. Alessandro Castorina

Guest Editor


Manuscript Submission Information

Manuscripts should be submitted online at https://jour.ipublishment.com/imr/access/login by registering and logging into this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Integrative Neuroscience is an international peer-reviewed open access quarterly journal published by IMR Press.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is $1500. We normally offer a discount greater than 30% (APC: $1050) to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.


Keywords

Neuropeptides, mood disorders, acute stress, chronic stress, depression, PTSD, affective spectrum, sleep disorders, binge eating, anxiety, depression


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Published Papers (1 paper)
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Effects of maternal immune activation in porcine transcript isoforms of neuropeptide and receptor genes
Bruce R. Southey, Pan Zhang, Marissa R. Keever, Haley E. Rymut, Rodney W. Johnson, Jonathan V. Sweedler, Sandra L. Rodriguez-Zas
Journal of Integrative Neuroscience    2021, 20 (1): 21-31.   DOI: 10.31083/j.jin.2021.01.332
Abstract158)   HTML13)    PDF(pc) (2953KB)(113)       Save

The prolonged effects of maternal immune activation in response stressors during gestation on the offspring's molecular pathways after birth are beginning to be understood. An association between maternal immune activation and neurodevelopmental and behavior disorders such as autism and schizophrenia spectrum disorders has been detected in long-term gene dysregulation. The incidence of alternative splicing among neuropeptides and neuropeptide receptor genes, critical cell-cell signaling molecules, associated with behavior may compromise the replicability of reported maternal immune activation effects at the gene level. This study aims to advance the understanding of the effect of maternal immune activation on transcript isoforms of the neuropeptide system (including neuropeptide, receptor and connecting pathway genes) underlying behavior disorders later in life. Recognizing the wide range of bioactive peptides and functional receptors stemming from alternative splicing, we studied the effects of maternal immune activation at the transcript isoform level on the hippocampus and amygdala of three-week-old pigs exposed to maternal immune activation due to viral infection during gestation. In the hippocampus and amygdala, 29 and 9 transcript isoforms, respectively, had maternal immune activation effects (P-value < 0.01). We demonstrated that the study of the effect of maternal immune activation on neuropeptide systems at the isoform level is necessary to expose opposite effects among transcript isoforms from the same gene. Genes were maternal immune activation effects have also been associated with neurodevelopmental and behavior disorders. The characterization of maternal immune activation effects at the transcript isoform level advances the understanding of neurodevelopmental disorders and identifies precise therapeutic targets.
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