#### Special Issues

Special Issue Title: Alzheimer’s disease (AD)

· Deadline for manuscript submissions: 1 August 2020

Special Issue Editor

Guest Editor

 Dr. Dhruba Pathak   Department of Anatomy & Neurobiology, Boston University School of Medicine

Interests: Biophysics of Neurons, neurotransmission, patch clamp recording, ion channels, intracellular recording, exosomes

Special Issue Information

Dear Colleagues,

Alzheimer's disease (AD) is one of the most debilitating neurodegenerative diseases of our times affecting many brain areas including those center regulating thought, memory, motor tasks, and language. In 2014, 5 million of the population in USA were living with AD and it is expected to reach 14 million by 2060. In this disease, amyloid- β (Aβ) accumulates to form plaques, and tau aggregates to form tangles. During this process pathological signaling cascades are also activated by inflammation, oxidative stress, enzymatic process etc. An interesting manuscript reviewed by Hampel et al. 2010 showed that interventions that slow down the clinical onset of dementia by 1 year would decrease the prevalence of AD by 9 million cases in 2050. However, little is known about the disease and progression of AD.
Because of the lack of appropriate cure targeting AD, families are facing economic burden and mental disturbance. For instance, in 2040, these costs are projected to jump to between $379 and more than$500 billion annually. In addition, it is well established that AD is one of the top 10 leading cause of death in the United States. This special issue particularly focuses on the mechanisms to dissect Alzheimer’s diseases by converging different perspectives together. We believe that by advancing the currents state of knowledge, one could formulate a better strategy of therapeutic intervention. Journal of Integrative Neuroscience (JIN) encourages both the submission original discovery and use of the latest tools and technology in the field of AD. We are highly enthusiastic to welcome the manuscripts that preferentially fall under this topic to advance the field forward.

In summary, we encourage researchers and academicians all around the world to disseminate their original findings in the form of research papers, mini-reviews, opinions, letter to editors, short communication towards stimulating diagnosis, nature, cause, therapeutic interventions and public health aspects of AD issues.

Dr. Dhruba Pathak

Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at https://jour.ipublishment.com/imr/access/login by registering and logging into this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the page. Journal of Integrative Neuroscience is an international peer-reviewed open access quarterly journal published by IMR Press.

Please visit thepage before submitting a manuscript. The for publication in this open access journal is $1500. We normally offer a discount greater than 30% (APC:$1050) to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

Keywords

Neurophysiology, structure & function, therapeutic intervention

Published Papers (1 paper)
 Select Identification, characterization and expression profiles of PSEN2 in the Chinese tree shrew (Tupaia belangeri chinensis) Mingxue Li, Wenguang Wang, Dexuan Kuang, Leiying Ruan, Xiaohui Li, Xin Huang, Xiaomei Sun, Jiejie Dai, Caixia Lu Journal of Integrative Neuroscience    2020, 19 (2): 249-257.   DOI: 10.31083/j.jin.2020.02.28 Abstract （307）   HTML （6）    PDF（pc） （7140KB）（328）       Save The gene PSEN2 encodes presenilin-2, a subunit of γ-secretase. Mutations in PSEN2 are not only related to Alzheimer's disease but are also involved in other diseases. The Chinese tree shrew (Tupaia belangeri chinensis) is a potential animal model for Alzheimer's disease, although little is known about its cDNA sequence, protein structure, and PSEN2 expression. To better understand PSEN2 in the tree shrew, we cloned this gene by rapid amplification of cDNA ends technology. Hence, we analyzed the sequence and molecular characteristics of PSEN2 mRNA, predicted its spatial structure, and analyzed its expression profiles. We found that tree shrew PSEN2 is 1539 base pairs in length and encodes 330 amino acids. It is homologous and genetically similar to humans (97.64% identity). The protein structure of tree shrew PSEN2 indicated similarities to human PSEN2, both being comprised of numerous transmembrane helices. However, tree shrew PSEN2 possesses seven α-helices, and thus lacks three compared with human PSEN2. Tree shrew PSEN2 mRNAs were ubiquitously detected in all tissues, with a tissue- and temporal-specific pattern. These results pave the way towards the function of tree shrew PSEN2, which will give insights into the mechanisms leading to neurodegenerative and other diseases in humans.

#### Current Issue

• Volume 20, Issue 1