#### Special Issues

Special Issue Title: Exploration of mechanisms in cortical plasticity

· Deadline for manuscript submissions: 1 August 2020

Special Issue Editor

Guest Editor

 Prof. Dr. Tetsuya Asakawa 1. Research Base of Traditional Chinese Medicine Syndrome, Fujian University of Traditional Chinese Medicine  2. Department of Neurosurgery, Hamamatsu University School of Medicine. Handayama, 1-20-1, Higashi-ku, Hamamatsu-city, Shizuoka, 431-3192, Japan

Interests: Neurology, functional neurosurgery, behavioral science, molecular imaging, neurophysiology, TCM research (herb, acupuncture, etc)

 Adjunct Research Assistant Prof. Rodolfo Gatto  Department of Bioengineering, University of Illinois at Chicago, 851 S Morgan St, SEO 218 Chicago, IL 60607, USA

Interests: Neuroimaging techniques & algorithms, neurodegenerative diseases and traumatic brain injury

Special Issue Information

Dear Colleagues,

Cortical plasticity, also known as neural plasticity, neuroplasticity or brain plasticity, is defined as a neurobiological ability of the nervous system to change its biophysiological functions by forming new neural connections. Therefore, it is a constant and dynamic remodeling process that allows the incorporation of new information. Such structural changes in neuronal connectivity, by cortical and subcortical rewiring of neuronal circuits, are extremely important mechanisms to adapt and survive continuously changing environments. Despite the increasing scientific attention to the cortical plasticity, its mechanisms have not been fully understood due to their complicated and multifold nature. In the last decades, the understanding of basic molecular, functional and associate ultrastructural remodeling mechanisms has gained momentum in diverse neuroscientific fields. With the recent advance of new genetic tools and non-invasive neuroimaging systems in the context of in vivo and in vitro studies, the assessment of synaptic and neuronal network changes across different cortical regions is achievable. Moreover, some of those techniques are making it possible to monitor in real-time new neural connections induced by several neurorehabilitation interventions. Such potential adaptability in neuronal connectivity has also been observed in the situation of aging, injury, and neurodegeneration as a potential therapeutic approached to restore the loss in several cortical functions. Furthermore, since most of the neuronal damages induced by diverse neurological diseases are irreversible, and the next-generation therapies like stem cell transplantation and gene therapy are far from been widely used in clinical practice, treatments associated with cortical plasticity are expected to improve the disease’s prognosis. In this topic, we are welcoming authors from any related basic and clinical fields to contribute with original research articles in a growing effort to illustrate different cortical plasticity mechanisms using diverse scientific methods. Therefore, the main goal of this topic is to provide the reader with a wide overview of current knowledge in the neuroplasticity field and the state-of-the-art application of novel cellular, animal and clinical experimental procedures to explore and enhance such mechanisms of neuronal restoration. Investigations using a “bench to bedside” translation approaches are particularly encouraged. Original research reports, review articles, communications, and perspectives are welcome in all areas pertinent to the topic.

Prof. Dr. Tetsuya Asakawa and Prof. Dr. Rodolfo G. Gatto

Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at https://jour.ipublishment.com/imr/access/login by registering and logging into this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a double-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the page. Journal of Integrative Neuroscience is an international peer-reviewed open access quarterly journal published by IMR Press.

Please visit thepage before submitting a manuscript. The for publication in this open access journal is $1500. We normally offer a discount greater than 30% (APC:$1050) to all contributors invited by the Editor-in-Chief, Guest Editor (GE) and Editorial board member. Submitted papers should be well formatted and use good English.

Keywords

Cortical plasticity, neuronal regeneration, neuronal and axonal connectivity, adaptative neuronal networks, neuronal restoration and repair, neurorehabilitation, neuroimaging

Published Papers (8 papers)
 Select A meta-analysis of case studies and clinical characteristics of hypertrophic olivary degeneration secondary to brainstem infarction Yi-Lin Wang, Yan Gao, Ping-Ping He, Jiang-Ning Yin, Ruo-Fei Dong, Xin Li, Yu Fu, Hong Zhang Journal of Integrative Neuroscience    2020, 19 (3): 507-511.   DOI: 10.31083/j.jin.2020.03.1238 Abstract （165）   HTML （18）    PDF（pc） （1013KB）（279）       Save Transsynaptic degeneration in the cerebellum and brainstem may give rise to a rare neurological condition with various clinical manifestations, namely hypertrophic olivary degeneration. The classical manifestations of hypertrophic olivary degeneration comprise myoclonus, palatal tremor, ataxia, and ocular symptoms. Any lesions interrupting the dentate-rubro-olivary pathway, referred to as the anatomic Guillain-Mollaret triangle, contribute to the broad aetiologies of hypertrophic olivary degeneration. The clinical diagnosis depends primarily on the associated symptoms and the characteristic magnetic resonance imaging findings. Concerning treatment and prognosis, there are no widely accepted guidelines. Here, we identified 11 cases of hypertrophic olivary degeneration secondary to brainstem infarction from 1964 to the present. Combined with two of our cases, the clinical and imaging findings of 13 patients with hypertrophic olivary degeneration secondary to brainstem infarction were studied. A meta-analysis of case studies gives the correlation coefficient between infraction location and time to develop hypertrophic olivary degeneration as 0.217 (P = 0.393, P $>$ 0.05). At the significance level of P $<$ 0.05, there was no significant correlation between infraction location and time to develop hypertrophic olivary degeneration. The $\chi{}^{2}$ between infraction location and magnetic resonance imaging findings of hypertrophic olivary degeneration was 8.750 (P = 0.364, P $>$ 0.05). At the significance level of P $<$ 0.05, there was no significant correlation between infraction location and magnetic resonance imaging findings of hypertrophic olivary degeneration. Conclusion based on the analysis of available data suggests that when newly developed or progressive worsening motor symptoms are presented in patients with previous brainstem infarction, a diagnosis of hypertrophic olivary degeneration should be investigated.