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Journal of Integrative Neuroscience  2021, Vol. 20 Issue (1): 95-101    DOI: 10.31083/j.jin.2021.01.366
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Thyrotroph embryonic factor polymorphism predicts faster progression of Parkinson's disease in a longitudinal study
Ping Hua1, Can Cui2, Yong Chen3, Yan Yao1, Cui-Yu Yu1, Li-Gang Xu1, Wei-Guo Liu1, *()
1Department of Neurology, Affiliated Brain Hospital of Nanjing Medical University, No. 264 Guangzhou Road, Nanjing, 210029 Jiangsu Province, P. R. China
2Department of Neurology, Shanghai East Hospital Affiliated to Tongji University, 150 Jimo Road, Pudong New Area, 201200 Shanghai, P. R. China
3Department of Clinical Laboratory, Affiliated Brain Hospital of Nanjing Medical University, No. 264 Guangzhou Road, Nanjing, 210029 Jiangsu Province, P. R. China
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Abstract  
The thyrotroph embryonic factor gene is a circadian clock-controlled gene. The rs738499 polymorphism of this gene has been suggested to be associated with depression and sleep disturbance in Parkinson's disease in previous cross-sectional studies. We aimed to investigate whether this single nucleotide polymorphism is associated with the progression rates of various motor and non-motor symptoms in patients with Parkinson's disease. We recruited 186 patients with Parkinson's disease for a longitudinal study. Motor and non-motor symptoms were assessed at baseline and follow-up, and 170 Parkinson's disease patients completed the clinical evaluation twice with an average follow-up period of 3.3 ± 1.1 years. A stepwise linear regression model was used to validate factors associated with Parkinson's disease symptoms' annual progression rates. Faster annual worsening rates of sleep quality and Hoehn-Yahr stage were found in carriers with the homozygous dominant (TT). After adjustment for related clinical factors, the rs738499 polymorphism showed a contribution of 3.1% to the annual decline rate on the Parkinson's Disease Sleep Scale score and a contribution of 5.5% to the annual increase rate of the Hoehn-Yahr stage. Additionally, anxiety and axial symptoms predicted the progression of sleep disturbances and motor staging. The TT genotype of rs738499 might be a potential predictor of rapid deterioration in sleep quality and Hoehn-Yahr stage in patients with Parkinson's disease and may advance the understanding of the genetic contributions to Parkinson's disease.
Key words:  Parkinson's disease      Sleep      Thyrotroph embryonic factor      Circadian genes      Longitudinal study     
Submitted:  02 November 2020      Revised:  10 December 2020      Accepted:  12 January 2021      Published:  30 March 2021     
Fund: 
81571348/National Natural Science
BK20151077/Jiangsu Natural Science Foundation
2016YFC1306600/National key research and development plan
2017YFC1310302/National key research and development plan
*Corresponding Author(s):  Wei-Guo Liu     E-mail:  liuweiguo1100@sina.com

Cite this article: 

Ping Hua, Can Cui, Yong Chen, Yan Yao, Cui-Yu Yu, Li-Gang Xu, Wei-Guo Liu. Thyrotroph embryonic factor polymorphism predicts faster progression of Parkinson's disease in a longitudinal study. Journal of Integrative Neuroscience, 2021, 20(1): 95-101.

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https://jin.imrpress.com/EN/10.31083/j.jin.2021.01.366     OR     https://jin.imrpress.com/EN/Y2021/V20/I1/95

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