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Journal of Integrative Neuroscience  2021, Vol. 20 Issue (1): 77-85    DOI: 10.31083/j.jin.2021.01.302
Original Research Previous articles | Next articles
Estrogen receptor 2 mediates intraspecific aggressive behaviors of the female Cricetulus barabensis in the estrous cycle
Jin-Hui Xu1, , Hui-Liang Xue1, , Zhe Wang1, Chao Fan1, Ming Wu1, Lai-Xiang Xu1, *()
1College of Life Sciences, Qufu Normal University, Qufu, 273165 Shandong, P. R. China
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Abstract  
The social behavior mechanisms have not been thoroughly reported in the solitary female striped dwarf hamster (Cricetulus barabensis). In this study, the handling bag test and neutral arena measurements were used to detect the changes of aggression in the face of rivals of different genders of wild striped dwarf hamsters. We found that female hamsters had the highest aggressive performance in proestrus, followed by estrus, and the lowest in metestrus and the dioestrus, and the increased aggression during the proestrus or estrus period was low-intensity aggression such as intimidation, shock, boxing and counterattack, or even ritualized non-harmful behaviors to drive away opponents. When confronted with male individuals, aggression in females decreased significantly during estrus. The concentration of plasma estradiol was the highest in estrus and the lowest in metestrus and dioestrus. In contrast, estrogen receptor 2 relative expression in the hypothalamus is the lowest in proestrus and highest in metestrus and dioestrus. Besides, both estradiol levels in plasma and estrogen receptor 2 mRNA in the hypothalamus were associated with aggression. These results will broaden our understanding of the molecular mechanism of how breeding phenotype is an essential driver in changing the social behavior of female Cricetulus barabensis.
Key words:  Hypothalamus      Behavioral endocrinology      Estrous cycle      Estrogen receptor 2      Social behavior mechanisms      Rodent     
Submitted:  29 September 2020      Revised:  10 December 2020      Accepted:  18 January 2021      Published:  30 March 2021     
Fund: 
31670385/National Natural Science Foundation of China
31570377/National Natural Science Foundation of China
31770455/National Natural Science Foundation of China
*Corresponding Author(s):  Lai-Xiang Xu     E-mail:  xulx@qfnu.edu.cn
These authors contributed equally.

Cite this article: 

Jin-Hui Xu, Hui-Liang Xue, Zhe Wang, Chao Fan, Ming Wu, Lai-Xiang Xu. Estrogen receptor 2 mediates intraspecific aggressive behaviors of the female Cricetulus barabensis in the estrous cycle. Journal of Integrative Neuroscience, 2021, 20(1): 77-85.

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https://jin.imrpress.com/EN/10.31083/j.jin.2021.01.302     OR     https://jin.imrpress.com/EN/Y2021/V20/I1/77

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