Journal of Integrative Neuroscience  2019, Vol. 18 Issue (1): 79-85    DOI: 10.31083/j.jin.2019.01.126
 Original Research Previous articles | Next articles
Cerebral cortex functional networks of magnetic stimulation at acupoints along the pericardium meridian
Yang-yang Dai1, 2, Ning Yin1, 2, *(), Hongli Yu1, 2, Gui-zhi Xu1, 2
1 State Key Laboratory of Reliability and Intelligence of Electrical Equipment, Hebei University of Technology, Tianjin, 300130, China
2 Key Laboratory of Electromagnetic Field and Electrical Apparatus Reliability of Hebei Province, Hebei University of Technology, Tianjin, 300130, China
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Abstract

The coordinated regulating mechanism of magnetic stimulation at acupoints along the pericardium meridian was studied by cerebral cortical functional networks. Electroencephalogram signals of 14 subjects (eight males and six females) were recorded in resting state and following magnetic stimulation at Neiguan and Daling acupoints along the pericardium meridian. The corresponding cortical functional networks were constructed and analyzed by group independent component analysis, standard low-resolution brain electromagnetic tomography, short-time Fourier transform, and complex network theory. Results showed that during magnetic stimulation at Daling and Neiguan acupoints, the functional connections of the nodes in the brain areas associated with movement respectively decreased by 7.3% and 19.9%, and the functional connections of the nodes in brain areas associated with advanced cognitive functions such as emotion, memory and language respectively increased by 24.9% and 18.8%. Changes of topological structure were similarly related to the efficacy of acupoints along the pericardium meridian. Magnetic stimulation also caused different topological changes consistent with the therapeutic function of specific acupoint. This study provided new evidence revealing mechanisms of brain functional integration and network synergy in the acupoint stimulation pathway.

Submitted:  07 December 2018      Accepted:  26 March 2019      Published:  30 March 2019
Fund:
• 51707055,51877067, 51877068, 51677053/Natural Science Foundation of China

• E2016202155/Natural Science Foundation of Hebei Province, China

*Corresponding Author(s):  Ning Yin     E-mail:  yinning@hebut.edu.cn

Yang-yang Dai, Ning Yin, Hongli Yu, Gui-zhi Xu. Cerebral cortex functional networks of magnetic stimulation at acupoints along the pericardium meridian. Journal of Integrative Neuroscience, 2019, 18(1): 79-85.

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Figure 1.  Position of acupoints. (a) PC7. It is located at the midpoint of the carpal palmar transverse stripe. (b) PC6. It is located five centimeters above the midpoint of the carpal palmar transverse stripe.

Figure 2.  Schematic diagram of experiment time line. EEG signals of resting state, stimulation at PC7 and PC6 respectively recorded for 60 seconds.

Figure 3.  Source localization of the EEG component. It gives the results of source localization from three directions. The current density gradually increases from the middle of the color bar to either side.

Figure 4.  The binary matrix (a) Resting state. (b) Stimulation at PC7. (c) Stimulation at PC6. The abscissa and ordinate represent the serial number of nodes. White represents the element in the matrix is 1, and black represents 0.

Figure 5.  $\alpha$-wave cortical cerebral functional network. (a) Resting state. (b) Stimulation at PC7. (c) Stimulation at PC6. The columns from left to right represent the sagittal, axial, and coronal directions. The small red spheres and blue lines respectively give the node locations and the connection edges between nodes.

Figure 6.  Number and mean degree of nodes in each Brodmann Area. (a) Number ofnodes. A dotted line with circle, square, and triangle respectively indicates the number of nodes in each BA of the resting state and the magnetic stimulation at PC7 and PC6. (b) Mean degree of nodes. White, gray, and black histograms respectively show the mean degree of nodes in each BA of the resting state, and magnetic stimulation at PC7 and PC6.

Table 1  The number of connections in specific functional areas.