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Journal of Integrative Neuroscience  2021, Vol. 20 Issue (1): 87-93    DOI: 10.31083/j.jin.2021.01.378
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Punicalagin effect on total sleep deprivation memory deficit in male Wistar rats
Mohammad Nasehi1, Mohammad-Hossein Mohammadi-Mahdiabadi-Hasani2, Mohammad-Reza Zarrindast1, Shahram Zarrabian3, *()
1Cognitive and Neuroscience Research Center (CNRC), Tehran Medical Sciences, Islamic Azad University, 18116-94784 Tehran, Iran
2Institute for Cognitive Science Studies (ICSS), 16583-44575 Tehran, Iran
3Department of Anatomical Sciences & Cognitive Neuroscience, Faculty of Medicine, Tehran Medical Sciences, Islamic Azad University, 19395-1495 Tehran, Iran
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Sleep deprivation has deteriorating effects on cognitive functions and activation of brain inflammation mechanisms has been reported by some studies following total sleep deprivation. Some studies have reported the health benefits of punicalagin, a main abstract from Punica granatum L., including those for the treatment of Alzheimer's disease. The antioxidant characteristic of punicalagin and the fact that sleep deprivation accelerates mediators of inflammation led us to further explore the possible neuroprotective role of punicalagin in total sleep deprivation memory impairment in a rat model. In this study, male Wistar rats were implanted with a canula in the lateral ventricle to receive intracerebroventricular injections (drug or vehicle). The animals were trained for the passive avoidance test and then received intracerebroventricular injections of different doses of punicalagin (0.001, 0.01, or 0.1 μg/rat). Then, they were placed in the sleep deprivation apparatus for 24 hours and tested afterwards for memory retrieval and locomotion. Our results indicated that 24 hours of total sleep deprivation impaired memory processes. PG microinjection before TSD did not prevent the deteriorating effect of total sleep deprivation on memory, and only showed a tendency of restoring the memory impairment. Comparison of the locomotor activity between the animals in different groups showed a significant increase in the total sleep deprivation sham groups that received two of the highest doses of punicalagin. Considering the reported beneficial actions of PG by other studies, further investigation is needed into the possible effects of PG in memory alterations.
Key words:  Punicalagin (PG)      Total sleep deprivation (TSD)      Memory deficit      Male rats     
Submitted:  08 October 2020      Revised:  21 December 2020      Accepted:  23 February 2021      Published:  30 March 2021     
1369704250005/Tehran Medical Sciences, Islamic Azad University
*Corresponding Author(s):; (Shahram Zarrabian)   

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Mohammad Nasehi, Mohammad-Hossein Mohammadi-Mahdiabadi-Hasani, Mohammad-Reza Zarrindast, Shahram Zarrabian. Punicalagin effect on total sleep deprivation memory deficit in male Wistar rats. Journal of Integrative Neuroscience, 2021, 20(1): 87-93.

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