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Journal of Integrative Neuroscience  2020, Vol. 19 Issue (2): 313-319    DOI: 10.31083/j.jin.2020.02.14
Original Research Previous articles | Next articles
Neuropsychological and neuroimaging assessments of early cognitive impairment in patients after mild ischemic stroke and transient ischemic attack
Yingxia Yang1, Lichao Ye1, Ruoting Lin1, Huasong Lin1, Ting Tang1, Yafang Chen1, Jinying Zhang1, Lingxing Wang1, *()
1Department of Neurology, The Second Affiliated Hospital of Fujian Medical University. Quanzhou, Fujian Province, 362000, P. R. China
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Abstract  
This study aimed to identify markers of early cognitive impairment after acute mild ischemic cerebrovascular disease. To further explore the relationship between neuroimaging markers of vascular and neurodegenerative injuries and post-stroke cognitive impairment, 86 patients with transient ischemic attack/acute mild ischemic stroke were recruited. Demographic information, clinical data, stroke scale scores (Modified Rankin Scale, National Institutes of Health Stroke Scale), and neuroimaging parameters (medial temporal lobe atrophy, global cortical atrophy, white matter hyperintensities, location and number of acute infarcts) were collected. All participants underwent neuropsychological evaluation at the time of discharge. The neurocognitive assessment was conducted using the Montreal Cognitive Assessment-Basic and Trail-Making Test A. It was found that low Montreal Cognitive Assessment-Basic scores were associated with global cortical atrophy and lower education levels. The completion time on the Trail-Making Test A was significantly correlated with medial temporal lobe atrophy and less education. It is concluded that global cortical atrophy and lower education levels can be used as rapid indicators of early cognitive impairment in patients after a transient ischemic attack and acute mild ischemic stroke. Medial temporal lobe atrophy also appears to be associated with mental processing speed in patients after a transient ischemic attack and acute mild ischemic stroke.
Key words:  Neuropsychological assessment      cognitive impairment      post-stroke      global cortical atrophy      medial temporal lobe atrophy      Montreal Cognitive Assessment-Basic      Trail-Making Test A     
Submitted:  21 January 2020      Revised:  01 May 2020      Accepted:  06 May 2020      Published:  30 June 2020     
Fund: 
2018QH1104/Fujian Medical University
*Corresponding Author(s):  Lingxing Wang     E-mail:  lxing502@fjmu.edu.cn

Cite this article: 

Yingxia Yang, Lichao Ye, Ruoting Lin, Huasong Lin, Ting Tang, Yafang Chen, Jinying Zhang, Lingxing Wang. Neuropsychological and neuroimaging assessments of early cognitive impairment in patients after mild ischemic stroke and transient ischemic attack. Journal of Integrative Neuroscience, 2020, 19(2): 313-319.

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https://jin.imrpress.com/EN/10.31083/j.jin.2020.02.14     OR     https://jin.imrpress.com/EN/Y2020/V19/I2/313

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[2] Dai Han, Shenxun Shi, Hong Luo. The therapeutic effect of quetiapine on cognitive impairment associated with 5-HT1A presynaptic receptor involved schizophrenia[J]. Journal of Integrative Neuroscience, 2019, 18(3): 245-251.
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