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Journal of Integrative Neuroscience  2020, Vol. 19 Issue (2): 385-395    DOI: 10.31083/j.jin.2020.02.1246
Systematic Review Previous articles |
Antidepressant pathways of the Chinese herb jiaweisinisan through genetic ontology analysis
Jie Chen1, , Yunling Huang1, , Ling Li1, Jie Niu1, Weiqiong Ye1, Yunnan Wang1, Can Yan1, *(), Lili Wu1, *()
1Research Center for Integrative Medicine of Guangzhou University of Chinese Medicine, Guangzhou, 510006, P. R. China
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Abstract  
Active compounds and corresponding targets of the traditional Chinese herb, jiaweisinisan, were obtained from systems pharmacological database and placed into ClueGO for gene ontology analysis. The targets of depression were obtained from the Online Mendelian Inheritance in Man, the Therapeutic Target Database, and the Pharmacogenomics Knowledge Base. Compound-target and target-pathway networks were constructed using Cytoscape, and then their topological parameters were analyzed. The targets of jiaweisinisan and depression were mapped to pathways, thereby constructing antidepressant pathways of jiaweisinisan. It was found that jiaweisinisan has 82 different active compounds and 306 relevant potential targets. Also, 107 unrepeatable targets related to depression were found. In all, 26 common targets were found to be the direct anti-depression targets of jiaweisinisan and 9 pathways of jiaweisinisan related to depression were divided into three modules (synaptic transmission, cell apoptosis, and immune-inflammatory). The jiaweisinisan formula was found to have synergistic antidepressant effects due to aspects of its herb composition and the active compounds therein, giving rise to potential targets and signaling pathways related to depression. Its antidepressant mechanisms were found to mainly involve the regulation of synaptic transmission, cell apoptosis, and immune-mediated inflammation.
Key words:  Systems neuropharmacology      gene ontology      depression      neuroinformatics      neurogenetics      antidepressant mechanisms      traditional Chinese herbs     
Submitted:  25 November 2019      Revised:  07 June 2020      Accepted:  08 June 2020      Published:  30 June 2020     
Fund: 
81573858/National Natural Science Foundation of China
2016A030313648/Natural Science Foundation of Guangdong Province, P. R. China
2017KZDXM020/Major Basic Research Project of Educational Commission of Guangdong Province, P. R. China
*Corresponding Author(s):  wulili@gzucm.edu.cn (Lili Wu) and yc1970@gzucm.edu.cn (Can Yan)   
These authors contributed equally.

Cite this article: 

Jie Chen, Yunling Huang, Ling Li, Jie Niu, Weiqiong Ye, Yunnan Wang, Can Yan, Lili Wu. Antidepressant pathways of the Chinese herb jiaweisinisan through genetic ontology analysis. Journal of Integrative Neuroscience, 2020, 19(2): 385-395.

URL: 

https://jin.imrpress.com/EN/10.31083/j.jin.2020.02.1246     OR     https://jin.imrpress.com/EN/Y2020/V19/I2/385

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