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Journal of Integrative Neuroscience   2019, Vol. 18 Issue (4): 377-385    DOI: 10.31083/j.jin.2019.04.1192
Original Research Previous articles | Next articles
Efficacy of remote limb ischemic conditioning on poststroke cognitive impairment
Xiaofang Feng1, 2, Lihong Huang2, Zongwen Wang3, Luojun Wang2, Xunhao Du2, Qi Wang2, Shouru Xue1, *()
1 Department of Neurology, the First Affiliated Hospital of Soochow University, Jiangsu Province, 215006, P. R. China
2 Department of Neurology, Zhabei Central Hospital, Jing'an District, Shanghai 200070, P. R. China
3 Department of Neurology, Tianyou Hospital, Tongji University, Shanghai 200331, P. R. China
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The impact of remote limb ischemic conditioning on post-stroke cognitive impairment was evaluated with 104 first-time patients of noncardiac ischemic stroke. During the acute phase the patients were randomized into control and remote limb ischemic conditioning groups. Both groups received standard treatment, while the remote limb ischemic conditioning group received additional remote limb ischemic conditioning treatment for 6 months. All participants underwent neuropsychological evaluation, transcranial Doppler detection, P300 event-related potential and brachial-ankle pulse wave velocity measurements, and determination of serum intercellular adhesion molecule-1 and endothelin-1 levels both at admission and 6 months poststroke. The number of cases with poststroke cognitive impairment in each group was evaluated 6 months poststroke. No statistically significant difference was found in demographic data or baseline detection indices at admission between the two groups. However, at 6 months poststroke, the remote limb ischemic conditioning group had significantly higher total Montreal Cognitive Assessment score and its domains of visuospatial and executive functioning and attention scores, significantly lower activity of daily living scale score, shorter P300 latency, and higher amplitude compared with the control group. Moreover, the middle cerebral artery, average blood flow velocity was significantly higher, while the middle cerebral artery-pulsation index, basilar artery pulsation index, and the levels of brachial-ankle pulse wave velocity, intercellular adhesion molecule-1, and endothelin-1 were significantly lower in the remote limb ischemic conditioning group compared with the control group. These results demonstrate that remote limb ischemic conditioning causes a significant improvement in cognitive domains, such as visuospatial and executive functioning and attention, and is therefore linked with reduced incidence of poststroke cognitive impairment.
Key words:  Event-related potential P300      stroke      cognitive impairment      ischemic conditioning      remote limb      vascular neurology     
Submitted:  10 October 2019      Accepted:  28 November 2019      Published:  30 December 2019     
2018MS11/Foundation of Municipal Health Commission of Jing'an District, Shanghai
*Corresponding Author(s):  Shouru Xue     E-mail:

Cite this article: 

Xiaofang Feng, Lihong Huang, Zongwen Wang, Luojun Wang, Xunhao Du, Qi Wang, Shouru Xue. Efficacy of remote limb ischemic conditioning on poststroke cognitive impairment. Journal of Integrative Neuroscience , 2019, 18(4): 377-385.

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